p-Fluorobromobenzene
p-Fluorobromobenzene: High-Quality Organic Intermediate for Industrial Applications
p-Fluorobromobenzene is a vital organic intermediate widely used in pharmaceutical, agrochemical, and material science industries. This halogenated aromatic compound offers excellent reactivity for various cross-coupling reactions and serves as a building block for complex molecular structures.
Product Specifications
- Chemical Name: 1-Bromo-4-fluorobenzene
- CAS Number: 460-00-4
- Molecular Formula: C6H4BrF
- Molecular Weight: 175.00 g/mol
- Appearance: Clear colorless to pale yellow liquid
- Purity: ≥98% (GC analysis)
- Boiling Point: 152-154°C
- Melting Point: -16°C
- Density: 1.593 g/mL at 25°C
- Refractive Index: n20/D 1.525
- Flash Point: 46°C
Technical Data Table
| Parameter | Specification |
|---|---|
| Assay (GC) | ≥98% |
| Water Content | ≤0.5% |
| Residue on Evaporation | ≤0.1% |
| Heavy Metals (as Pb) | ≤10 ppm |
| Storage Temperature | 2-8°C |
| Shelf Life | 24 months |
| Packing | 25kg/drum, 200kg/drum or customized |
Key Features of p-Fluorobromobenzene
- High chemical purity and consistent quality
- Excellent reactivity for nucleophilic substitution
- Stable under normal storage conditions
- Compatible with various coupling reactions (Suzuki, Stille, Negishi)
- Low impurity profile for demanding applications
Applications
- Pharmaceutical intermediates synthesis
- Agrochemical active ingredients production
- Liquid crystal material precursor
- Organic electronic materials manufacturing
- Research and development applications
p-Fluorobromobenzene FAQ
What safety precautions should be taken when handling p-Fluorobromobenzene?
p-Fluorobromobenzene should be handled in a well-ventilated area with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and lab coat. Avoid inhalation of vapors and contact with skin or eyes. In case of exposure, immediately flush affected areas with plenty of water and seek medical attention. Store away from heat sources and oxidizing agents.
What is the best storage condition for p-Fluorobromobenzene?
For optimal stability, p-Fluorobromobenzene should be stored in a cool (2-8°C), dry place in tightly sealed original containers protected from light and moisture. Under these conditions, the product maintains its quality for at least 24 months. For long-term storage, consider using amber glass bottles or chemically compatible plastic containers.
How is p-Fluorobromobenzene typically used in pharmaceutical synthesis?
In pharmaceutical applications, p-Fluorobromobenzene serves as a versatile building block for various drug candidates. The bromine atom readily participates in cross-coupling reactions (such as Suzuki or Buchwald-Hartwig couplings) to form biaryl structures, while the fluorine atom can be used for further functionalization or as a metabolic stabilizer. This compound is particularly valuable in the synthesis of fluorinated drug molecules where the fluorine atom enhances bioavailability and metabolic stability.
Quality Assurance
Our p-Fluorobromobenzene undergoes rigorous quality control procedures including GC-MS analysis, HPLC purity testing, and moisture content determination. Each batch is accompanied by a Certificate of Analysis detailing all quality parameters. We implement strict GMP-compliant manufacturing processes to ensure batch-to-batch consistency and reliability for your critical applications.
Packaging Options
| Package Size | Container Type | Gross Weight |
|---|---|---|
| 25 kg | HDPE drum with inner liner | 28 kg |
| 200 kg | HDPE drum with inner liner | 210 kg |
| 1 kg | Amber glass bottle | 1.2 kg |
| Custom | Various options available | Variable |
Ordering Information
p-Fluorobromobenzene is available in various package sizes to meet your specific requirements. For sample requests, bulk orders, or technical inquiries, please contact our sales team with your desired quantity, purity specifications, and delivery requirements. We offer flexible shipping solutions including expedited delivery for urgent requirements.