2-Chloro-4-methylsulfonylbenzoic acid
2-Chloro-4-methylsulfonylbenzoic acid is a versatile chemical compound widely used in pharmaceutical and agrochemical industries. This white crystalline powder offers excellent stability and reactivity, making it a preferred choice for various synthetic applications.
Product Specifications
- Chemical Name: 2-Chloro-4-methylsulfonylbenzoic acid
- CAS Number: 53948-05-9
- Molecular Formula: C8H7ClO4S
- Molecular Weight: 234.66 g/mol
- Appearance: White to off-white crystalline powder
- Purity: ≥98% (HPLC)
- Melting Point: 180-185°C
- Solubility: Soluble in organic solvents like methanol, ethanol, and DMSO
Detailed Technical Parameters
| Parameter | Specification | Test Method |
|---|---|---|
| Assay (HPLC) | ≥98% | HPLC |
| Loss on Drying | ≤0.5% | Karl Fischer |
| Residue on Ignition | ≤0.1% | Gravimetric |
| Heavy Metals | ≤10 ppm | ICP-MS |
| Related Substances | ≤1.0% total | HPLC |
Applications of 2-Chloro-4-methylsulfonylbenzoic acid
2-Chloro-4-methylsulfonylbenzoic acid serves as a key intermediate in the synthesis of various pharmaceutical compounds, particularly in the production of non-steroidal anti-inflammatory drugs (NSAIDs). Its unique chemical structure makes it valuable for creating novel therapeutic agents with improved efficacy and reduced side effects.
Storage and Handling
Store 2-Chloro-4-methylsulfonylbenzoic acid in a cool, dry place away from direct sunlight and moisture. Maintain temperature between 15-25°C in tightly sealed containers. The compound is stable under recommended storage conditions for at least 24 months.
FAQ - 2-Chloro-4-methylsulfonylbenzoic acid
Q: What is the shelf life of 2-Chloro-4-methylsulfonylbenzoic acid?
A: When stored properly in sealed containers under recommended conditions, 2-Chloro-4-methylsulfonylbenzoic acid maintains its quality for at least 24 months. The actual shelf life may extend beyond this period if storage conditions are strictly maintained.
Q: Can 2-Chloro-4-methylsulfonylbenzoic acid be used in pharmaceutical formulations?
A: Yes, 2-Chloro-4-methylsulfonylbenzoic acid serves as an important intermediate in pharmaceutical synthesis. However, it should undergo further purification and processing according to specific pharmaceutical requirements before being incorporated into final drug formulations.
Q: What safety precautions should be taken when handling 2-Chloro-4-methylsulfonylbenzoic acid?
A: Always use appropriate personal protective equipment including gloves, safety glasses, and lab coat when handling 2-Chloro-4-methylsulfonylbenzoic acid. Work in a well-ventilated area and avoid inhalation of dust. In case of skin contact, wash immediately with plenty of water.
Q: Is 2-Chloro-4-methylsulfonylbenzoic acid soluble in water?
A: 2-Chloro-4-methylsulfonylbenzoic acid has limited solubility in water but dissolves well in various organic solvents including methanol, ethanol, and dimethyl sulfoxide (DMSO).
Q: What analytical methods are used for quality control of 2-Chloro-4-methylsulfonylbenzoic acid?
A: High-performance liquid chromatography (HPLC) is the primary method for purity assessment. Additional tests include melting point determination, residual solvent analysis by GC, and elemental analysis for verification of molecular structure.
Packaging Options
We offer 2-Chloro-4-methylsulfonylbenzoic acid in various packaging sizes to meet different customer needs:
- 25g amber glass bottles
- 100g amber glass bottles
- 500g polypropylene containers
- 1kg polyethylene containers
- Custom packaging available upon request
Quality Assurance
Our 2-Chloro-4-methylsulfonylbenzoic acid undergoes rigorous quality control testing to ensure compliance with international standards. Each batch is accompanied by a Certificate of Analysis detailing specific test results and confirming compliance with specifications.