4-Chloroacetoacetic acid ethyl ester
4-Chloroacetoacetic acid ethyl ester - High-Quality Chemical Solution
4-Chloroacetoacetic acid ethyl ester, also known as ethyl 4-chloroacetoacetate, is a versatile chemical compound widely used in pharmaceutical synthesis, agrochemical production, and organic chemistry research. This ester derivative of acetoacetic acid offers exceptional reactivity and purity, making it a preferred choice for various industrial applications.
Product Specifications
- Chemical Name: 4-Chloroacetoacetic acid ethyl ester
- CAS Number: 638-07-3
- Molecular Formula: C6H9ClO3
- Molecular Weight: 164.59 g/mol
- Appearance: Clear colorless to pale yellow liquid
- Purity: ≥98% (GC)
- Boiling Point: 215-217°C
- Density: 1.192 g/cm³ at 25°C
- Refractive Index: n20/D 1.438
- Flash Point: 96°C
| Parameter | Value |
|---|---|
| Solubility | Soluble in most organic solvents (ethanol, ether, chloroform), slightly soluble in water |
| Storage Conditions | Keep tightly closed in a cool, dry place (2-8°C recommended) |
| Stability | Stable under recommended storage conditions |
| Hazard Class | Irritant (Xi) |
| Transport Information | Not regulated for transport |
| Shelf Life | 24 months when properly stored |
Applications
4-Chloroacetoacetic acid ethyl ester serves as a key intermediate in numerous chemical processes:
- Pharmaceutical synthesis (especially for cardiovascular drugs)
- Agrochemical production (herbicides and pesticides)
- Dye and pigment manufacturing
- Organic synthesis of heterocyclic compounds
- Research and development applications
Frequently Asked Questions
Q: What is the proper handling procedure for 4-Chloroacetoacetic acid ethyl ester?
A: Always wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and lab coat when handling 4-Chloroacetoacetic acid ethyl ester. Work in a well-ventilated area or fume hood. Avoid contact with skin, eyes, and clothing. In case of contact, immediately flush with plenty of water for at least 15 minutes and seek medical attention if irritation persists.
Q: How should 4-Chloroacetoacetic acid ethyl ester be stored for optimal shelf life?
A: 4-Chloroacetoacetic acid ethyl ester should be stored in tightly closed containers made of glass or chemically resistant plastic. Keep containers in a cool, dry place away from direct sunlight and heat sources. Refrigeration at 2-8°C is recommended for long-term storage. Ensure proper labeling and segregation from incompatible materials such as strong bases and oxidizing agents.
Q: What analytical methods are used to verify the purity of 4-Chloroacetoacetic acid ethyl ester?
A: The purity of 4-Chloroacetoacetic acid ethyl ester is typically verified using gas chromatography (GC) with flame ionization detection, achieving ≥98% purity. Additional characterization methods include: infrared spectroscopy (IR) for functional group identification, nuclear magnetic resonance (NMR) spectroscopy for structural confirmation, and Karl Fischer titration for water content determination.
Safety Information
- Hazard Statements: H315 (Causes skin irritation), H319 (Causes serious eye irritation)
- Precautionary Statements: P280 (Wear protective gloves/protective clothing/eye protection/face protection), P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes)
- First Aid Measures: Eye contact - rinse immediately with plenty of water; Skin contact - wash with soap and water; Inhalation - move to fresh air; Ingestion - rinse mouth and seek medical advice
Key Features
- High purity grade (≥98%) suitable for critical applications
- Consistent batch-to-batch quality
- Stable chemical properties
- Versatile reactivity profile
- Available in various packaging sizes (from 100g to 25kg)
Ordering Information
Our 4-Chloroacetoacetic acid ethyl ester is available in different quantities to meet your specific requirements. Contact our sales team for current pricing, lead times, and shipping options. Custom synthesis and special packaging solutions are available upon request.