3-Chloropropyne
3-Chloropropyne: High-Purity Chemical Compound for Industrial Applications
3-Chloropropyne, also known as propargyl chloride, is an important intermediate in organic synthesis with CAS number 624-65-7. This colorless to pale yellow liquid has wide applications in pharmaceutical, agrochemical, and specialty chemical industries.
Key Product Specifications
- Chemical Name: 3-Chloropropyne (Propargyl Chloride)
- CAS Number: 624-65-7
- Molecular Formula: C3H3Cl
- Molecular Weight: 74.51 g/mol
- Appearance: Colorless to pale yellow liquid
- Purity: ≥98% (GC analysis)
- Boiling Point: 57-59°C
- Flash Point: -7°C (closed cup)
- Density: 1.03 g/cm3 at 25°C
- Refractive Index: nD20 = 1.434
Storage and Handling
| Parameter | Specification |
|---|---|
| Storage Temperature | 2-8°C in well-sealed containers |
| Shelf Life | 12 months when properly stored |
| Packaging | 1kg, 5kg, 25kg steel drums or custom packaging |
| Hazard Class | 3 (Flammable liquid), 6.1 (Toxic) |
| UN Number | UN 2345 |
Common Applications
- Pharmaceutical intermediates synthesis
- Agrochemical production
- Specialty chemicals manufacturing
- Corrosion inhibitors
- Polymer modification
3-Chloropropyne Safety Information
| Safety Parameter | Value/Information |
|---|---|
| Flash Point | -7°C (highly flammable) |
| Autoignition Temperature | 350°C |
| Explosive Limits | 3.1-14.0% (volume in air) |
| GHS Hazard Statements | H225, H301, H311, H315, H319, H331, H335 |
3-Chloropropyne FAQ Section
1. What are the main storage requirements for 3-Chloropropyne?
3-Chloropropyne must be stored in tightly sealed containers under inert atmosphere (nitrogen or argon) at temperatures between 2-8°C. Storage areas should be well-ventilated, away from heat sources and protected from direct sunlight. Containers should be grounded during transfer to prevent static electricity buildup. Never store near oxidizers or strong bases.
2. What is the typical lead time for 3-Chloropropyne orders?
For standard purity grades (≥98%), we maintain stock for immediate shipment with lead times of 3-5 business days for domestic orders and 7-10 days for international shipments. Custom purity grades (≥99%) may require 2-3 weeks for production and quality control testing before shipment. Large bulk orders (≥1000kg) typically require 4-6 weeks advance notice.
3. What safety precautions are required when handling 3-Chloropropyne?
Always work with 3-Chloropropyne in a fume hood with proper PPE including chemical-resistant gloves (nitrile or neoprene), splash goggles, and flame-resistant lab coat. The area should have explosion-proof electrical equipment. Have class B fire extinguishers (CO2, dry chemical) readily available. Avoid inhalation of vapors and skin contact. In case of spill, absorb with inert material and dispose as hazardous waste according to local regulations.
Technical Grade Specifications
| Parameter | Standard Grade | High Purity Grade |
|---|---|---|
| Purity (GC) | ≥98.0% | ≥99.5% |
| Water Content | ≤0.5% | ≤0.1% |
| Acidity (as HCl) | ≤0.2% | ≤0.05% |
| Color (APHA) | ≤50 | ≤20 |
Shipping Information
3-Chloropropyne is classified as a hazardous material for transportation (UN 2345, Class 3/6.1). All shipments comply with IATA/IMDG/ADR regulations. We offer both air and sea freight options with temperature-controlled containers available upon request. Minimum order quantity is 1kg, with standard packaging in amber glass bottles or specially lined steel drums for larger quantities.
Additional 3-Chloropropyne FAQ
4. What analytical methods are used for quality control of 3-Chloropropyne?
We employ multiple analytical techniques to ensure 3-Chloropropyne quality: Gas Chromatography (GC-FID) for purity assessment (typically using DB-624 columns), Karl Fischer titration for water content, potentiometric titration for acidity determination, and ICP-MS for heavy metal analysis. Each batch is accompanied by a Certificate of Analysis detailing these parameters.
5. Are there any known incompatibilities with 3-Chloropropyne?
3-Chloropropyne is incompatible with strong oxidizers (may cause fire/explosion), strong bases (can lead to violent polymerization), and active metals (may form explosive acetylides). It reacts vigorously with amines and can form explosive peroxides when exposed to air over time. Always consult the MSDS before combining with other chemicals.
6. What is the typical shelf life of 3-Chloropropyne?
When stored properly (2-8°C under inert atmosphere in dark containers), 3-Chloropropyne typically maintains specification for 12 months. Beyond this period, we recommend requalification through GC analysis. For maximum stability, small aliquots should be taken from storage rather than repeatedly opening main containers. Stabilized grades with additives are available upon request for extended storage needs.
Detailed Application Notes
In pharmaceutical applications, 3-Chloropropyne serves as a key building block for various drug intermediates. Its reactive chlorine and alkyne groups allow versatile transformations including nucleophilic substitutions, Sonogashira couplings, and click chemistry reactions. In agrochemicals, it's used in the synthesis of certain fungicides and plant growth regulators. The specialty chemical industry utilizes it for modifying polymers and creating corrosion inhibitors.