m-Aminotrifluorotoluene
m-Aminotrifluorotoluene is a highly specialized chemical compound widely used in pharmaceutical and agrochemical industries. With its unique trifluoromethyl and amino functional groups, this compound serves as a crucial intermediate in organic synthesis. Below, we provide a detailed technical overview of m-Aminotrifluorotoluene, including specifications, applications, and frequently asked questions.
Product Specifications
- Chemical Name: m-Aminotrifluorotoluene
- CAS Number: 98-16-8
- Molecular Formula: C7H6F3N
- Molecular Weight: 161.12 g/mol
- Appearance: Clear to pale yellow liquid
- Purity: ≥98%
- Boiling Point: 185-187°C
- Density: 1.32 g/cm³ at 25°C
- Flash Point: 68°C
Physical & Chemical Properties
| Property | Value |
|---|---|
| Solubility in Water | Slightly soluble |
| Solubility in Organic Solvents | Miscible with most organic solvents |
| Refractive Index | 1.468-1.470 |
| Vapor Pressure | 0.5 mmHg at 20°C |
| Storage Conditions | Store in cool, dry place under inert atmosphere |
Applications of m-Aminotrifluorotoluene
m-Aminotrifluorotoluene serves as a key building block in various industries:
- Pharmaceutical intermediates for drug synthesis
- Agrochemical formulations for crop protection
- Liquid crystal materials for electronic displays
- Specialty dyes and pigments
- Flavor and fragrance compounds
Frequently Asked Questions
Question: What precautions should be taken when handling m-Aminotrifluorotoluene?
Answer: When handling m-Aminotrifluorotoluene, always use appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and lab coat. Work in a well-ventilated area or fume hood. Avoid contact with skin, eyes, and clothing. Store away from oxidizing agents and strong acids. In case of accidental exposure, immediately flush affected areas with plenty of water and seek medical attention if irritation persists.
Question: What is the shelf life of m-Aminotrifluorotoluene?
Answer: m-Aminotrifluorotoluene has a typical shelf life of 24 months when stored properly in its original sealed container under recommended conditions (cool, dry place, protected from light and moisture at temperatures below 30°C). For optimal stability, it's recommended to store under inert atmosphere (nitrogen or argon). Always check the material before use if stored for extended periods.
Question: Can m-Aminotrifluorotoluene be used in peptide synthesis?
Answer: Yes, m-Aminotrifluorotoluene serves as a valuable intermediate in peptide synthesis, particularly for introducing trifluoromethyl groups into peptide structures. The trifluoromethyl group can significantly alter the biological activity, metabolic stability, and lipophilicity of peptides. However, specific reaction conditions and protection strategies for the amino group must be carefully considered to achieve successful incorporation into peptide chains.
Packaging Information
| Package Size | Material | Quantity |
|---|---|---|
| Lab Scale | Glass Bottle | 100g, 500g |
| Pilot Scale | HDPE Drum | 5kg, 10kg |
| Industrial Scale | Steel Container | 25kg, 50kg, 200kg |
Safety Data
m-Aminotrifluorotoluene should be handled with care:
- Hazard Statements: H302 Harmful if swallowed, H315 Causes skin irritation, H319 Causes serious eye irritation, H335 May cause respiratory irritation
- Precautionary Statements: P261 Avoid breathing dust/fume/gas/mist, P280 Wear protective gloves/protective clothing/eye protection/face protection
- First Aid Measures: For inhalation, move to fresh air. For skin contact, wash with soap and water. For eye contact, rinse cautiously with water for several minutes.
Quality Control
Every batch of m-Aminotrifluorotoluene undergoes rigorous testing:
| Test Parameter | Method | Specification |
|---|---|---|
| Purity (GC) | ASTM E260 | ≥98.0% |
| Water Content | Karl Fischer | ≤0.5% |
| Impurities | GC-MS | ≤2.0% total |
| Heavy Metals | ICP-MS | ≤10 ppm |
With its unique chemical properties and versatility, m-Aminotrifluorotoluene remains an important compound for research and industrial applications. Our high-purity product meets the stringent requirements of pharmaceutical and specialty chemical industries.