p-Fluorobenzaldehyde
Premium Quality p-Fluorobenzaldehyde for Industrial Applications
p-Fluorobenzaldehyde (CAS 456-48-4) is a versatile aromatic aldehyde widely used in pharmaceutical intermediates, agrochemicals, and specialty chemical synthesis. Our high-purity p-Fluorobenzaldehyde meets the most stringent quality standards for industrial and laboratory applications.
Key Specifications
- Chemical Name: 4-Fluorobenzaldehyde
- CAS Number: 456-48-4
- Molecular Formula: C7H5FO
- Molecular Weight: 124.11 g/mol
- Appearance: Clear colorless to pale yellow liquid
- Purity: ≥98.5% (GC)
- Boiling Point: 185-187°C
- Melting Point: -10°C
- Density: 1.176 g/cm³ at 25°C
- Flash Point: 72°C
Technical Parameters
| Parameter | Specification | Test Method |
|---|---|---|
| Assay (GC) | ≥98.5% | GC-FID |
| Water Content | ≤0.5% | KF Titration |
| Residue on Ignition | ≤0.1% | Gravimetric |
| Heavy Metals (as Pb) | ≤10 ppm | ICP-OES |
| Related Substances | ≤1.0% (total) | HPLC |
Storage and Handling
Store p-Fluorobenzaldehyde in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly closed when not in use. Recommended storage temperature: 2-8°C. Shelf life: 24 months when stored properly.
Packaging Options
- 1kg glass bottles
- 5kg plastic jerry cans
- 25kg polyethylene drums
- 200kg stainless steel drums
- Custom packaging available upon request
p-Fluorobenzaldehyde FAQ
What are the main applications of p-Fluorobenzaldehyde?
p-Fluorobenzaldehyde serves as a key intermediate in pharmaceutical synthesis, particularly for fluorinated drug compounds. It's widely used in the production of antihistamines, anti-inflammatory drugs, and antifungal agents. In agrochemicals, it's utilized for creating novel pesticides and herbicides. Additionally, it finds applications in liquid crystal materials, dyes, and specialty polymers.
Is p-Fluorobenzaldehyde hazardous?
p-Fluorobenzaldehyde is classified as harmful if swallowed, causes skin irritation, and serious eye irritation. It may cause respiratory irritation and is toxic to aquatic life. Proper personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and protective clothing should be worn when handling. Always work in a well-ventilated area or fume hood.
How should p-Fluorobenzaldehyde be transported?
p-Fluorobenzaldehyde should be transported as hazardous material according to local regulations. For international shipments, it's classified under UN number 1989, Class 3, Packing Group III. Transport containers must be properly labeled with hazard symbols and handled by trained personnel. Ground transportation should use properly secured, leak-proof containers with appropriate hazard placards.
What's the difference between p-Fluorobenzaldehyde and similar compounds?
p-Fluorobenzaldehyde differs from other benzaldehyde derivatives primarily by its fluorine atom in the para position. This substitution pattern gives it unique electronic properties compared to non-fluorinated benzaldehydes or those with substituents in other positions (ortho or meta). The fluorine atom increases the compound's stability and affects its reactivity in subsequent chemical transformations.
Can p-Fluorobenzaldehyde be used in pharmaceutical GMP production?
Yes, our p-Fluorobenzaldehyde is available in GMP-grade for pharmaceutical applications. The GMP version undergoes additional purification steps, more stringent quality controls, and comprehensive documentation including certificates of analysis, traceability, and full regulatory support. Batch-to-batch consistency is rigorously maintained to meet pharmaceutical requirements.
What analytical methods are used for quality control?
We employ multiple analytical techniques for quality assurance of p-Fluorobenzaldehyde: Gas Chromatography (GC) for purity analysis, Karl Fischer titration for water content, HPLC for impurity profiling, ICP-OES for heavy metal testing, and NMR for structural confirmation. Each batch is thoroughly characterized before release.